![]() ![]() This position statement outlines the rationale for current recommended empirical therapy using a third-generation cephalosporin and vancomycin for suspected bacterial meningitis. Diagnosis still rests on clinical signs and symptoms, and cerebrospinal fluid analysis. However, this infection continues to be associated with considerable mortality and morbidity if not treated effectively with empirical antimicrobial therapy. The incidence of bacterial meningitis in infants and children has decreased since the routine use of conjugated vaccines targeting Haemophilus influenzae type b, Streptococcus pneumoniae, and Neisseria meningitidis. Updated by Nicole Le Saux, Infectious Diseases and Immunization Committee Nicole Le Saux Canadian Paediatric Society.
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